Read e-book online Dynamics of Membrane Assembly PDF

By Anthony P. Pugsley (auth.), Jos A. F. Op den Kamp (eds.)

ISBN-10: 3662028603

ISBN-13: 9783662028605

ISBN-10: 366202862X

ISBN-13: 9783662028629

The assembly on "Dynamics of Membrane Assembly.", backed by means of NATO clinical Affairs department as a complicated research Institute and by means of FEBS as a Lecture path used to be held in Cargese, France, in June 1991. this system integrated introductory lectures, really good up to date contributions and poster periods. Emphasis was once laid at the new advancements within the box of membrane biogenesis, specifically at the biosynthesis of phospholipids and the applying of recent genetic suggestions in those reviews; at the membrane insertion and translocation of proteins; on intracellular protein and membrane site visitors; and at the mutual interactions among a number of the occasions taking place in the course of membrane biogenesis. a lot growth in those examine parts has been made in recent times and the ASI supplied a great chance to demonstrate this growth compared to prior conferences on the same subject. not just graduate scholars and postdocs took virtue from this application but additionally skilled scientists got the chance to procure an entire evaluate of contemporary growth and the remodelling of rules and concepts.

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Nature 347:561-562 Bankaitis VA, Malehorn DE, Emr SD, Greene R (1989) The Saccharoymyces cerevisiae SEC14 gene encodes a cytosolic factor that is required for transport of secretory proteins from the yeast Golgi complex. J Cell BioI 108:1271-1281 Bohin J-P, Kennedy EP (1984) Regulation of the synthesis of membranederived oligosaccharides in Escherichia coli. J BioI Chern 259: 8388-8393 Carman GM, Henry SA (1989) Phospholipid biosynthesis in yeast. Annu Rev Biochem 58:635-669 Chang C-F, Shuman H, Somlyo AP (1986) Electron probe analysis, X-ray mapping, and electron energy-loss spectroscopy of calcium, magnesium, and monovalent ions in log-phase and in dividing Escherichia coli B cells.

Since all of these gene fusions will result in some low level of read through, it should be possible to isolate by pass or suppressor mutations for each of these steps analogous to the lpp suppression of the lacOP-pgsA fusion. Analysis of such mutations will lead to a better understanding of the function of phospholipids. Relationship Movement Between Intracellular Phospholipid and Protein In E. coli it is clear that acidic phospholipids play an important role in the process of movement of proteins through the inner membrane.

1991]. The subsequent threestep methylation of its product, phosphatidylethanolamine, to the major cellular phospholipid, phosphatidylcholine, is located in the endoplasmic reticulum. This poses an interesting question as to the inter-membrane regulation of different metabolic steps in the PtdCho biosynthetic cascade. Localization of enzymes in different membrane compartments may well play an important role in the control of substrate flow through the biosynthetic pathways. Elucidation of the factors controlling PSD activity should thus provide some hints on the mechanisms involved in controlling cellular lipid synthesis.

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Dynamics of Membrane Assembly by Anthony P. Pugsley (auth.), Jos A. F. Op den Kamp (eds.)

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