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Additional info for Dynamics of Human Development: Achievement Crisis (Working Paper)

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Synapse 2007;61(12):991–1001. E. Y. Tseng 83. Manning-Bog AB, McCormack AL, Li J, Uversky VN, Fink AL, Di Monte DA. The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein. J Biol Chem 2002;277(3):1641–4. 84. Thiruchelvam M, Richfield EK, Baggs RB, Tank AW, Cory-Slechta DA. The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined –paraquat and maneb: implications for Parkinson’s disease. J Neurosci 2000;20(24):9207–14.

Cognitive deficits in Parkinson’s disease. J Neurol 1997;244(1):2–8. 25. Lees AJ, Smith E. Cognitive deficits in the early stages of Parkinson’s disease. Brain 1983;106 (Pt 2):257–70. 26. Owen AM, James M, Leigh PN, et al. Fronto-striatal cognitive deficits at different stages of Parkinson’s disease. Brain 1992;115 (Pt 6):1727–51. 27. Owen AM, Roberts AC, Hodges JR, Summers BA, Polkey CE, Robbins TW. Contrasting mechanisms of impaired attentional set-shifting in patients with frontal lobe damage or Parkinson’s disease.

Here the level of phasic dopamine could correspond to the degree of wanting of a certain reward. Along similar lines, the lab of Salamone has collected interesting data indicating a role for dopamine as a behavioral activator by acting as a substrate for motivation. , energy expenditure [39]. In keeping with this, one of the functions ascribed to phasic dopamine signaling is action selection [40]. The functional anatomy of the basal ganglia along with dopamine release in the striatum is believed to aid in promoting a motor behavior of desired intent while inhibiting competing motor behavior [41–44].

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