By Bertis Little
This functional instruction manual will support the medical professional and nurse prescriber in realizing the consequences of drug publicity while pregnant. a number of tables and packing containers offer details on drug classifications and regimens, in addition to highlighting opposed results and TERIS and FDA probability rankings. assets of extra details are supplied the place acceptable, and full references can be found at the book's site www.drugs-and-pregnancy.com.
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Extra resources for Drugs and Pregnancy: A Handbook (A Hodder Arnold Publication)
Hypertension, vascular disease, acute pyelonephritis) may alter ‘normal’ pregnancy-associated physiologic changes. Limited information on pharmacokinetics of most antimicrobial agents during pregnancy is available. 1 is adapted for antimicrobials. , 1983). , 1980). , increased volume of distribution) is probably the cause of lowered serum drug concentrations. Lower serum drug concentrations are probably not caused by strong dissociation of ampicillin at physiological pH, which should theoretically interfere with placental transfer.
ANTIPARASITICS Although parasitic infections are relatively common during pregnancy, therapy (with a few exceptions) can usually be withheld until after pregnancy since many such infections are mild and asymptomatic. Metronidazole, the only effective antiparasitic agent for trichomoniasis, has already been discussed (p. 30). 19 Pediculicides Lice infestation Lindane (Kwell, Scabene) Pyrethrins and piperonyl butoxide (RID, A200) Mite infestations Crotamiton (Eurax) Lindane (Kwell, Scabene) Sulfur (6%) in petrolatum Pediculicides Both lice (Pediculosis pubis) and mite (scabies) infestations during pregnancy generally require some form of therapy.
Many of these are for topical application. Nystatin, clotrimazole, and miconazole These agents are utilized primarily for the treatment of candidiasis. , 1987a). Butoconazole, terconazole, and ketoconazole There are no large studies of the use of these three antifungal agents during pregnancy. 14 Potential adverse fetal and maternal effects of rifampin, ethambutol, isoniazid and pyrazinamide Rifampin Fetal effects None known Isoniazid Fetal effects None known Maternal effects Discoloration of urine, feces, sweat, sputum, tears Gastrointestinal intolerance Headache, fatigue, myalgia, fever Hypersensitivity Maternal effects Gastrointestinal disturbance Hepatitis Hypersensitivity Peripheral neuritis Ethambutol Fetal effects None known Maternal effects Hypersensitivity Hyperuricemia Optic and peripheral neuritis Pyrazinamide Fetal effects Unknown Maternal effects Arthralgias Elevated liver enzymes Gastrointestinal disturbance Rash Adapted in part from the USP DI (United States Pharmacopeial Convention, 2003); PDR, 2004.
Drugs and Pregnancy: A Handbook (A Hodder Arnold Publication) by Bertis Little