By Shannon R. Blume, Kuei Y. Tseng (auth.), Kuei-Yuan Tseng (eds.)
Cortico-subcortical dynamics in Parkinson’s ailment goals to combine key pathophysiological features underlying Parkinson’s ailment. the quantity deals a vast spectrum of critiques on how continual dopamine depletion impacts cortico-subcortical dynamics, particularly how disruptions of the non-dopaminergic platforms due to persistent dopaminergic degeneration may lead to the practical changes saw in parkinsonism.
About the Editor:
Dr. Kuei Y. Tseng is Assistant Professor within the division of mobile and Molecular Pharmacology at Rosalind Franklin college of drugs and technological know-how, The Chicago scientific tuition, North Chicago, IL, USA.
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Additional info for Cortico-Subcortical Dynamics in Parkinson's Disease
Synapse 2007;61(12):991–1001. E. Y. Tseng 83. Manning-Bog AB, McCormack AL, Li J, Uversky VN, Fink AL, Di Monte DA. The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein. J Biol Chem 2002;277(3):1641–4. 84. Thiruchelvam M, Richfield EK, Baggs RB, Tank AW, Cory-Slechta DA. The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined –paraquat and maneb: implications for Parkinson’s disease. J Neurosci 2000;20(24):9207–14.
Cognitive deficits in Parkinson’s disease. J Neurol 1997;244(1):2–8. 25. Lees AJ, Smith E. Cognitive deficits in the early stages of Parkinson’s disease. Brain 1983;106 (Pt 2):257–70. 26. Owen AM, James M, Leigh PN, et al. Fronto-striatal cognitive deficits at different stages of Parkinson’s disease. Brain 1992;115 (Pt 6):1727–51. 27. Owen AM, Roberts AC, Hodges JR, Summers BA, Polkey CE, Robbins TW. Contrasting mechanisms of impaired attentional set-shifting in patients with frontal lobe damage or Parkinson’s disease.
Here the level of phasic dopamine could correspond to the degree of wanting of a certain reward. Along similar lines, the lab of Salamone has collected interesting data indicating a role for dopamine as a behavioral activator by acting as a substrate for motivation. , energy expenditure . In keeping with this, one of the functions ascribed to phasic dopamine signaling is action selection . The functional anatomy of the basal ganglia along with dopamine release in the striatum is believed to aid in promoting a motor behavior of desired intent while inhibiting competing motor behavior [41–44].
Cortico-Subcortical Dynamics in Parkinson's Disease by Shannon R. Blume, Kuei Y. Tseng (auth.), Kuei-Yuan Tseng (eds.)