Download e-book for iPad: Cancer of the Uterus by George Coukos, Stephen C. Rubin

By George Coukos, Stephen C. Rubin

ISBN-10: 0824754158

ISBN-13: 9780824754150

NTI/Sales reproduction: the one consultant to supply complete insurance of the administration of endometrial melanoma, in addition to cancers in, on, and round the uterus. reports the impression of diagnostic instruments, imaging recommendations, and sampling approaches within the review and administration of assorted cancers. Discusses overdue and complicated degree remedies together with radiation and surgical procedure.

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Atypical HNPCC owing to MSH6 germline mutations: analysis of a large Dutch pedigree. J Med Genetics 2001; 38:318–322. 25. Berends MJ, Wu Y, Sijmons RH, et al. Molecular and clinical characteristics of MSH6 variants: an analysis of 25 index carriers of a germline variant. Am J Hum Genetics 2002; 70:26–37. 26. Burke W, Petersen G, Lynch P, et al. Recommendations for follow-up care of individuals with an inherited predisposition to cancer. I. Hereditary nonpolyposis colon cancer. Cancer Genetics Studies Consortium.

These observations strongly support the notion that there is more than one suppressor on the long arm of chromosome 10 playing a role in uterine cancers. Careful evaluation of published LOH/deletion data suggests that there may be three tumor suppressor genes based on different regions and patterns of deletion in endometrioid tumors (115,117–119). A homeodomain gene, EMX2, was suggested as the candidate tumor suppressor mapping in the 10q25–q26 region (120). EMX2 mutations are Coukos01 001-034 11/18/04 16 1:32 PM Page 16 Goodfellow infrequent in endometrial cancers (10%) and additional studies are required to determine whether loss of EMX2 contributes to the development of uterine adenocarcinomas.

This syndrome was initially described by Aldred Warthin in 1895 when the striking family history of his seamstress, who died of endometrial cancer, came to his attention. In 1913, he published a paper describing this remarkable kindred, which included 10 cases of endometrial cancer and 7 cases of stomach cancer in 48 descendants of a man who died of cancer of the stomach or intestine (2). Multiple cases of colorectal cancer were noted in subsequent generations of this family (3). The HNPCC syndrome is also commonly called the Lynch Syndrome II, after Henry Lynch who systematically characterized this syndrome in the 1960s (4).

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Cancer of the Uterus by George Coukos, Stephen C. Rubin


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