Read e-book online Atlas of Gynecologic Oncology PDF

By J. Richard Smith, Giuseppe Del Priore, Robert L. Coleman, John M. Monaghan, John Curtin

ISBN-10: 1841843687

ISBN-13: 9781841843681

Absolutely up-to-date and revised, the second one variation of An Atlas of Gynecologic Oncology offers an entire description of the investigative and surgeries performed via the gynecologic oncologist. Key positive factors of this crucial textual content comprise:

  • a functional advisor to a variety of operative and investigative systems
  • contributions from overseas opinion leaders
  • over 450 color illustrations
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    Additional resources for Atlas of Gynecologic Oncology

    Sample text

    Html Page 30 growth of tumor cells and metastasis. It is also likely that cytokines produced by tumors will modulate immune responses that favor tumor progression (Nash et al. 1999). It is clear that cytokines do not fulfill the classic criteria for tumor markers. They are invariably produced by non-malignant tissue, may be elevated in a number of pathological conditions, are not specific for one cell type and in the malignant scenario are often produced by the surrounding tissue in response to the tumor rather then by the tumor itself.

    In contrast to Cytokeratins themselves, fragments of Cytokeratins are soluble in the serum and therefore can be detected and measured with the aid of monoclonal antibodies. Those currently being studied as tumor markers in ovarian cancer are tissue polypeptide-specific antigen (TPS), a proliferation marker recognized by a monoclonal antibody raised against cytokeratin 18 and CYFRA 21–1, a soluble serum fragment of cytokeratin 19. Elevated TPS levels may add to the diagnostic value of serum CA125 in ovarian cancer (Shabana and Onsrud 1994, Sliutz et al.

    While authors agree that raised levels reflect advanced stage and portend a poor prognosis, there is controversy as to whether this adds any information to that gained by history, physical examination, preoperative imaging and surgery (Cherchi et al. 1999, Schneider et al. 1999). CA125 rises progressively with worsening grade. It was suggested that it may have a role in posttreatment surveillance of patients with early-stage endometrial cancer. However, levels can be falsely elevated in the presence of severe radiation injury (Rose et al.

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    Atlas of Gynecologic Oncology by J. Richard Smith, Giuseppe Del Priore, Robert L. Coleman, John M. Monaghan, John Curtin


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